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一般外科、大腸直腸外科共同實驗室簡介

一般外科、大腸直腸外科共同實驗室

 

研究室成員:張群明醫師、吳晉嘉醫師、李政鴻醫師
 
研究簡介
 
一、研究主題
 

(探討Prostate apoptosis response-4 (Par-4)在肝癌所扮演之角色

(探討單核細胞驅化蛋白-1 (Monocyte Chemotactic Protein-1)在肝癌所扮演之角色

(大腸直腸癌相關研究

            ()CDX2與大腸直腸癌相關研究 

 
 
二、研究目的

肝癌 (Hepatomacellular CarcinimaHCC) 又稱肝腫瘤,是全世界上最普通的惡性原發性肝臟腫瘤,是目前在全球盛行率最高的惡性腫瘤之一。目前肝癌仍未有效之治療藥物,實有尋找新的腫瘤標記物之需要。本研究室在慈大李政偉教授及中正大學黃憲斌教授指導下,進行相關之研究,期望繼續發現有用的標記物,以利協助肝癌作為進行輔助性治療之參考因子。

近年來,對於風濕疾病的了解日益增加,而且許多風濕疾病和外科相關疾病亦有密不可分的關係。例如潰瘍性大腸炎和大腸直腸癌的發生,貝賽氏症和腸胃道穿孔的發生。而風濕病之病人也被認為是對手術較不利的因子。因此,我們設計此研究,期望用健保資料庫來探討風濕免疫科病與各種外科疾病之關係。

大腸癌是台灣癌症之首,大腸癌近幾年由於藥物的進步,其五年的存活率有大大提升,目前許多研究都在找尋更有效的藥物來提升存活率。我們因此希望能研究AZD8055在大腸癌的療效,並探究其相關機制。並期望繼續發現有用的標記物,以利協助大腸癌作為進行輔助性治療之參考因子。
 
 
 
計畫與經費來源
 
計畫編號
計畫名稱
經費來源
DTCRD102(2)-I-04
探討MCP-1調控肝癌增生、抗凋亡的分子
大林慈濟醫院
DTCRD103(2)-I-04
決定臨終前重症患者接受過度醫療之影響因子及其醫療費用之探討
大林慈濟醫院
DTCRD105(2)-E-18
探討Par-4在肝癌的角色及做為生物標記可能性評估
大林慈濟醫院
DTCRD105(2)-E-17
台灣之大腸直腸癌CDX2基因表現以及與預後之相關性
大林慈濟醫院
DTCRD106-E-04
探討在體外低氧預處理最適化條件下對結腸癌細胞株C2BBel增長的促進與在訊號路徑的作用機制影響
大林慈濟醫院
 
 
研究成果
 

張群明 Chang Chun-Ming

(A)期刊論文 

1.      Chang CM, Yin WY, Wei CK, Wu CC, Su YC, Yu CH, Lee CC. Adjusted Age-Adjusted Charlson Comorbidity Index Score as a Risk Measure of Perioperative Mortality before Cancer Surgery. PLoS One 2016 Feb 5; 11(2):e0148076.

2.      Chen LF, Chang CM, Huang CY. Home-Based Hospice Care Reduces End-of-Life Expenditure in Taiwan: A Population-Based Study. Medicine (Baltimore) 2015 Sep;94(38):e1613. 

3.      Hung YTHuang CYChang CMLee CC. The Association of Hematological Malignancy and End-of-Life Expenditure in Cancer Decedents: A Population-Based Study in an Asian Country. Medicine (Baltimore) 2015 Jul;94(26):e1036.

4.      Chen JH, Wei CK, Lee CH, Chang CM, Hsu TW, Yin WY. The safety and adequacy of resection on hepatocellular carcinoma larger than 10 cm: A retrospective study over 10 years. Ann Med Surg (Lond) 2015 May 14;4(2):193-9.

5.      Wu CC, Hsu TW, Chang CM, Yu CH, Lee CC. Age-adjusted Charlson comorbidity index scores as predictor of survival in colorectal cancer patients who underwent surgical resection and chemoradiation. Medicine (Baltimore) 2015 Jan;94(2):e431.

6.      Huang CY, Hung YT, Chang CM, Juang SY, Lee CC. The association between individual income and aggressive end-of-life treatment in older cancer decedents in Taiwan. PLoS One 2015 Jan 13;10(1):e0116913

7.      Hsieh CH, Wei CK, Yin WY, Chang CM, Tsai SJ, Wang LY, Chiou WY, Lee MS, Lin HY, Hung SK. Vascular invasion affects survival in early hepatocellular carcinoma. Mol Clin Oncol 2015 Jan;3(1):252-256. 

8.      Chiou WY, Chang CM, Tseng KC, Hung SK, Lin HY, Chen YC, Su YC, Tseng CW, Tsai SJ, Lee MS, Li CY. Effect of liver cirrhosis on metastasis in colorectal cancer patients: a nationwide population-based cohort study. Jpn J Clin Oncol. 2015 Feb;45(2):160-8.

9.      Chen JH, Chang CM, Lu MC, Wei CK, Yin WY. Delayed-Onset Chylous Ascites After a Living-Donor Liver Transplant: First Case Successfully Treated With Conservative Treatment? Exp Clin Transplant. 2014 Oct 31.

10.   Chang CM, Wu CC, Yin WY, Juang SY, Yu CH, Lee CC. Low socioeconomic status is associated with more aggressive end-of-life care for working-age terminal cancer patients. Oncologist 2014 Dec;19(12):1241-8.

11.   Chang CM, Yin WY, Su YC, Wei CK, Lee CH, Juang SY, Chen YT, Chen JC, Lee CC.Preoperative risk score predicting 90-day mortality after liver resection in a population-based study. Medicine (Baltimore). 2014 Sep;93(12):e59.

12.   Chang TS, Huang KY, Chang CM, Lin CH, Su YC, Lee CC. The association of hospital spending intensity and cancer outcomes: a population-based study in an Asian country. Oncologist 2014 Sep;19(9):990-8.

13.   Lee TF, Chao PJ, Ting HM, Chang L, Huang YJ, Wu JM, Wang HY, Horng MF, Chang CM, Lan JH, Huang YY, Fang FM, Leung SW. Using multivariate regression model with least absolute shrinkage and selection operator (LASSO) to predict the incidence of Xerostomia after intensity-modulated radiotherapy for head and neck cancer. PLoS One. 2014 Feb 28;9(2):e89700.

14.   Wu CC, Hsu TW, Chang CM, Yu CH, Wang YF, Lee CC. The effect of individual and neighborhood socioeconomic status on gastric cancer survival. PLoS One. 2014 Feb 25;9(2):e89655.

15.   Chang CM, Yin WY, Wei CK, Lee CH, Lee CC. The combined effects of hospital and surgeon volume on short-term survival after hepatic resection in a population-based study. PLoS One.2014 Jan 22;9(1):e86444.

16.   Chang CM, Yin WY, Wei CK, Lin CH, Huang KY, Lin SP, Lee CH, Chou P, Lee CC. The association of socioeconomic status and access to low-volume service providers in breast cancer. PLoS One. 2013 Dec 2;8(12):e81801.

17.   Chang TS, Chang CM, Ho HC, Su YC, Chen LF, Chou P, Lee CC. Impact of young age on the prognosis for oral cancer: a population-based study in taiwan. PLoS One. 2013 Sep 26;8(9):e75855

18.   Chang TS, Chang CM, Hsu TW, Lin YS, Lai NS, Su YC, Huang KY, Lin HL, Lee CC. The combined effect of individual and neighborhood socioeconomic status on nasopharyngeal cancer survival. PLoS One. 2013 Sep 12;8(9):e73889.

19.   Hsu TW, Lu HJ, Wei CK, Yin WY, Chang CM, Chiou WY, Lee MS, Lin HY, Su YC, Hung SK. Clinical and pathologic factors affecting lymph node yields in colorectal cancer. PLoS One. 2013 Jul 16;8(7):e68526.

20.   張群明,蔡任弼,李政鴻,尹文耀.C型肝炎與腎臟移植. 腎臟與透析 Kidney and Dialysis R.O.C. 2012/11;24(4):269-272

21.   Chang CM, Su YC, Lai NS, Huang KY, Chien SH, Chang YH, Lian WC, Hsu TW, Lee CC. The Combined Effect of Individual and Neighborhood Socioeconomic Status on Cancer Survival Rates. PLoS ONE. 2012/08;7(8):e44325.

22.   Chang CM, Huang KY, Hsu TW, Su YC, Yang WZ, Chen TC, Chou P, Lee CC.Multivariate Analyses to Assess the Effect of Surgeon and Hospital Volume on Cancer Sruvival Rates : A Nationwide Population-Based Study in Taiwan. PLoS ONE. 2012/07;7(7):e40590.

23.   Hong JC, Koroleff D, Xia V, Chang CM, Duarte SM, Xu J, Lassman C, Kupiec-Weglinski J, Coito AJ, Busuttil RW. Regulated hepatic reperfusion mitigates ischemia-reperfusion injury and improves survival after prolonged liver warm ischemia: a pilot study on a novel concept of organ resuscitation in a large animal model. J Am Coll Surg. 2012 Apr;214(4):505-15; discussion 515-6.

24.   Chang CM, Wei CK, Lee CH, Tseng KC, Lin CW, Yin WY. Long-Term Follow-Up of Central Hepatocellular Carcinoma in Comparison with Non-Central Hepatocellular Carcinoma. Hepato-gastroenterology. 2012/3-4;59(114):492-5

25.   Yin WY, Wei CK, Tseng KC, Lin SP, Lin CH, Chang CM, Hsu TW. Open colectomy versus laparoscopic-assisted colectomy supported by hand-assisted laparoscopic colectomy for resectable colorectal cancer: a comparative study with minimum follow-up of three years. Hepatogastroenterology. 2009,56(93):998-1006.

26.   Chang CM, Wei CK, Lin SP, Hsu DW, Lin CH. Case Report---Giant Right Hepatic Hemangioma. Tzu Chi Med J , 2008; 20(1):70–72.

27.   Chang CM, Lin CH, Lin SP, Hsu DW, Wei CK, Yin WY. Early Treatment for Symptomatic Giant Hepatic Hemangioma : Report of three cases and literature review. Surgery Journal, 2007, 2(4): 45-49.

(B)研討會論文

1.      Chun-Ming Chang, Ta-Wen Hsu, Yu-Chieh Su, Wei-Zhen Yang, Ching-Chih Lee. Multivariate analyses to assess the effects of surgeon and hospital volume on cancer survival rates: A nationwide population-based study in Taiwan.(102年度外科醫學會聯合學術研討會)

2.      Chun-Ming Chang, Wen-Yao Yin, Chang-Kao Wei, Ta-Wen Hsu, Chun-Hung Lin, Cheng-Hung Lee, Ching-Chih Lee.The Combined Effect of Individual and Neighborhood Socioeconomic Status on Cancer Survival Rates. (102年度外科醫學會聯合學術研討會)

3.      Chun-Ming Chang, Wen-Yao Yin, Chang-Kao Wei, Cheng-Hung Lee, Ching-Chih Lee. The Effect of Surgeon and Hospital Volume on Long-Term Survival for Hepatocellular Carcinoma after Hepatic Resection. (102年度外科醫學會聯合學術研討會)

4.      Chun-Ming Chang, Wen-Yao Yin, Cheng-Hong Lee, Jian-Han Chen, Kuo-Chih Tseng, Chih-Wen Lin, Chang-Kuo Wei. Long -Term Follow-Up of The Central Hepato-Cellular Carcinoma in Comparison with The Non-Centrals. (102年度外科醫學會聯合學術研討會)

5.      Chun-Ming Chang, Wen-Yao Yin, Cheng-Hong Lee, Jian-Han Chen, Kuo-Chih Tseng, Chih-Wei Tseng, Chih-Wen Lin, Chang-Kuo Wei. Donor Derived Cryptococcus Infection in Liver Transplantation: Case Report and Literature Review. (102年度外科醫學會聯合學術研討會)

6.      Chang CM, Yin WY, Lin CW. Acute-on-Chronic Mesenteric Ischemia Treat by Thrombolytic Therapy and Percutaneous Transluminal Angioplasty with a Stent (108 th Annual Congress of Japan Surgical Society, Travel Grant Award, Japan, 2008 )

7.      Chang CM, Hepatic Hemengioma, When to Operate? (Annual meeting of Taiwan Surgical Association, Taiwan,2007)

8.     Chang CM, Yin WY. A free peritoneal graft for the severe seromuscular defect of bowel : from experiment to clinical practice (106 th Annual

吳晉嘉 Chin-Chia Wu

期刊論文:

1.   Wu CC, Hsu Hsu TW, Chang CM, Lee CH, Huang CY, Lee CC(2016). Palliative Chemotherapy Affects Aggressiveness of End-of-Life Care. The Oncologist ( In Press) ( SCI, IF=4.865)

2.   Wu CC, Hsu TW, Chang CM, Yu CH, Wang YF, Lee CC (2014). The Combined Effect of Individual and Neighborhood Socioeconomic Status on Gastric Cancer Survival. PLOS ONE 2014 9(2), e89655. (SCI , I F =3.7).

3.   Wu CC, Hsu TW, Chang CM, Yu CH, Lee CC (2015). Age-adjusted Charlson comorbidity index scores as predictor of survival in colorectal cancer patients who underwent surgical resection and chemoradiation. Medicine (Baltimore). 2015 Jan;94(2):e431.(SCI, IF=4.867)

4.   Chang CM, Wu CC, Yin WY, Juang SY, Yu CH, Lee CC. Low socioeconomic status is associated with more aggressive end-of-life care for working-age terminal cancer patients. Oncologist. 2014 Dec;19(12):1241-8.( SCI, IF=4.54)

5.   Chen YL, Wang CY, Wu CC, Lee MS, Hung SK, Chen WC, Hsu CY, Hsu CW, Huang CY, Su YC, Lee CC.Prognostic influences of lymph node ratio in major cancers of Taiwan: a longitudinal study from a single cancer center. J Cancer Res Clin Oncol. 2015 Feb;141(2):333-43. (SCI, IF=3.009)

6.   Wu CC, Kang JC, Lai HJ, Chen HT, Lee MC, Huang YM (2012). Decision Making in the Management of Obscure-Overt Gastrointestinal Bleeding in Emergency Settings. J Soc Colon Rectal Surgeon (Taiwan) 2012 Sep, 83-91

7.   Wu CC, Kang JC, Huang YM(2012) Laparoscopic Transabdominal Preperitoneal Hernioplasty for Reduction En Masse of an Incarcerated Inguinal Hernia: A Case Report. Journal of Gastrointestinal Surgery  2012 Jul, 16(7), 1433-1435

  8.  Huang YM, Wu CC (2012) Whirl sign in small bowel volvulus. BMJ Case Reports. doi:10.1136/bcr-2012-006688.

李政鴻 Cheng-Hung Lee

期刊論文:

1.      Chen JH, Wei CK, Lee CH, Chang CM, Hsu TW, Yin WY. The safety and adequacy of resection on hepatocellular carcinoma larger than 10 cm: A retrospective studyover 10 years. Ann Med Surg . 2015 May 14;4(2):193-9.

2.      Lee CH, Yin WY, Chen JH. Gallstone ileus with jejunum perforation managed with laparoscopic-assisted surgery: rare case report and minimal invasive management.Int Surg. 2015 May;100(5):878-81.

3.       Lin WL, Su SF, Lee WJ, Lee CH. [The influence of bariatric surgery on body image in obesity patients]. Hu Li Za Zhi. 2015 Feb;62(1):50-7.

4.       Lee CH, Chen JH, Lin CH. An unusual cause of intestinal obstruction. ANZ J Surg. 2014 Sep 29.

5.      Chang CM, Yin WY, Su YC, Wei CK, Lee CH, Juang SY, Chen YT, Chen JC, Lee CC. Preoperative risk score predicting 90-day mortality after liver resection in a population-based study. Medicine (Baltimore). 2014 Sep;93(12):e59.

6.       Chen JH, Lee CH, Tseng CW. A female patient with persistent epigastric pain for 1 week. Gastroenterology. 2014 Sep;147(3):e5-6.

7.       Wei CK, Chang CM, Lee CH, Chen JH, Yin WY. Acute appendicitis in organ transplantation patients: a report of two cases and a literature review. Ann Transplant. 2014 May 23;19:248-52.

8.      Chang CM, Yin WY, Wei CK, Lee CH, Lee CC. The combined effects of hospital andsurgeon volume on short-term survival after hepatic resection in a population-based study. PLoS One. 2014 Jan 22;9(1):e86444.

9.     Chen JH, Lee CH, Wei CK, Chang SM, Yin WY. Undifferentiated embryonal sarcoma of the liver with focal osteoid picture-a case report. Asian J Surg. 2013 Oct;36(4):174-8.

 

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