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中醫藥研究室

中醫藥研究室

 

研究室成員:葉家舟醫師(主持人)、陳柏全醫師、葉明憲醫師、劉靜如

 

研究簡介

 
一、研究主題:
中藥對免疫系統之調控
中藥對致癌物及HBx對癌細轉移之抑制
中醫藥臨床對癌症患者之研究
二、研究目的:
中藥應用在治療癌症已早有研究,並且許多其萃取物已成為現代臨床治療之藥物,但僅限於殺滅癌細胞,不論各種殺滅癌細胞之藥物及方式已見成效,但畢竟有其極限,若要進一步的突破,不同的治療思考與模式就成為一種新治療的方向,中醫對癌細胞的治療屬整個有體的調節,本實驗室由中醫藥對癌症的轉移所牽涉的生理機制—細胞轉移的機制與免疫系統的調節,欲由此方向尋求新的整合型治療癌症的模式。
三、研究方法:
利用不同的癌細胞與免疫相關細胞(macrophage、lymphocyte、PMN等)經由TPA或發炎誘發物引發其轉移或發炎,經中藥的介入,視其轉移及發炎的抑制,進一步看其中藥在對這二種細胞間的交互物用,並在動物體上進行基本的藥物反應測試。另一方面進行臨床癌症者的病歷回顧,進行中藥介入癌症治療之成效與其可能的方向之發現。

 

計畫與經費來源

 

計 畫 名 稱
計畫內擔任之工作
起迄年月
補助機構
中醫療法是否能增加癌症患者之存活率?
主持人
105/07/01~106/06/30 慈濟醫療志業基金會
木犀草素對HBx誘發肝癌及脂肪肝之作用
主持人
105/02/01~107/01/31 佛教慈濟醫療財團法人大林慈濟醫院
木犀草素對抑制HBx所誘發之mTOR訊息途徑相關蛋白的表現及肝癌細胞轉移之研究
主持人
105/08/01~106/07/31 佛教慈濟醫療財團法人大林慈濟醫院
飛燕草素對TPA誘發肝癌細胞轉移之作用
主持人
104/02/01~105/01/31 佛教慈濟醫療財團法人大林慈濟醫院
夏枯草抑制TPA誘發之MMP-9之表現分子機制
主持人
103/02/01~104/01/31 佛教慈濟醫療財團法人大林慈濟醫院
5,7,4三羥基異黃酮抑制TPA誘發之MMP-9之表現分子機制
主持人
102/02/01~103/01/31 佛教慈濟醫療財團法人大林慈濟醫院
四逆散對抑制HBX所引發之MMP-9表現及肝癌細胞轉移之研究
主持人
101/08/01~102/07/31 佛教慈濟醫療財團法人大林慈濟醫院
中藥抑制HBx所引發之MMP-9表現及肝癌細胞轉移之研究
主持人
100.7~101.6
國科會
柚皮苷抑制TPA透發之MMP-9之表現分子機制
主持人
99.7~100.6
慈濟醫院
原綠酸與木犀草素之協同作用對內毒素誘發之敗血病細胞之研究
主持人
98.7~99.6
國科會
金銀花及其成份對內毒素誘發敗血症之抗發炎細胞激素IL-10之調節作用及分子機制
主持人
97.7~98.6
國科會
黃連萃取物對神經細胞再生之活體內外之研究
主持人
97.7~98.6
慈濟醫院
柚皮苷抑制LPS及乙醛誘發之MMP-9之表現分子機制
協同主持人
97.7~98.6
慈濟醫院
銀翹散及其成份對內毒素誘發敗血症之抗發炎細胞分子機制
主持人
97.1~98.6
慈濟醫院
金銀花及其成份對內毒素誘發敗血症之抗發炎細胞激素IL-10之調節作用及分子機制
主持人
97.7~98.6
國科會

 

 

 

研究成果

(A)期刊論文

  1. Tzung-Yi Tsai, Hanoch Livneh, Tsung-Hsing Hung, I -Hsin Lin, Ming-Chi Lu, Chia-Chou Yeh*.(2017) Associations between prescribed Chinese herbal medicine and risk of hepatocellular carcinoma in patients with chronic hepatitis B: a nationwide population-based cohort study. BMJ Open 2017;7: e014571. doi:10.1136/bmjopen-2016-014571 (SCI) (IF=2.562)
  2. Kuen-Hau Chen, Ming-Hsien Yeh, Hanoch Livneh, Bor-Chyuan Chen, I-Hsin Lin, Ming-Chi Lu, Tzung-Yi Tsai* and Chia-Chou Yeh*.(2017) Association of traditional Chinese medicine therapy and the risk of dementia in patients with hypertension: a nationwide population-based cohort study. BMC Complementary and Alternative Medicine 17:178 DOI 10.1186/s12906-017-1677-4. (SCI) (IF=2.02)
  3. Tzung-Yi Tsai, Chung-Yi Li, Hanoch Livneh, I-Hsin Lin, Ming-Chi Lu, Chia-Chou Yeh*. (2016 May) Decreased risk of stroke in patients receiving traditional Chinese medicine for vertigo: A population-based cohort study. J Ethnopharmacol.184:138-143. (SCI) (IF=2.998)
  4. Yu-Chieh Su, I-Hsin Lin, Yu-Miao Siao, Ching-Ju Liu, Chia-Chou Yeh*. (2016) Modulation of the Tumor Metastatic Microenvironment and Multiple Signal Pathways by Prunella vulgaris in Human Hepatocellular Carcinoma. Am J Chin Med. 44(4): 1–15. (SCI) (IF=2.755)
  5. 陳昆豪,葉家舟*(2016)從不明熱顯效病例談李東垣陰火診治特點.中醫藥研究論叢.19(1):181-193(SCI)
  6. 鄭秝丞、葉家舟*(2016)下咽癌病患空腸造口術術後腹脹之病例淺談小柴胡湯合小建中湯之用藥思考策略.中醫藥研究論叢.19(2);161-170(SCI)
  7. Yen HR, Liu CJ, Yeh CC*. (2015) Naringenin suppresses TPA-induced tumor invasion by suppressing multiple signal transduction pathways in human hepatocellular carcinoma cells. Chem Biol Interact. 235:1-9. (SCI) (IF=2.982)
  8. HJ Lin, ST Kao, YM Siao, CC Yeh*. (2015) The Chinese medicine Sini-San inhibits HBx-induced migration and invasiveness of human hepatocellular carcinoma cells. BMC complementary and alternative medicine. 15:348. (SCI) (IF=2.02)
  9. 廖厚勳,施秀雯,葉家舟*。(2015)小柴胡湯加減治療食道癌併發食道吞嚥困難之病例).中醫藥研究論叢. 18(2) : 87-96. (非SCI)
  10. 郭怡婷,葉家舟*。(2015)半夏白朮天麻湯加減治療多年頭痛之病例.中醫藥研究論叢. 18(1);65-75.(非SCI)
  11. Kao ST, Liu CJ, Yeh CC*. (2015) Protective and immunomodulatory effect of flos Lonicerae japonicae by augmenting IL-10 expression in a murine model of acute lung inflammation. J Ethnopharmacol.168:108-115. (SCI) (IF=2.939)
  12. Liao HH, Yeh CC, Lin CC, Chen BC, Yeh MH, Chang KM, Sun MF, Yen HR.(2015 Jul) Prescription Patterns of Chinese herbal products for Patients with Fractures in Taiwan: A nationwide population-based study. J Ethnopharmacol.173:11-19. (SCI) (IF=2.998)
  13. 楊紓怡,洪哲明,葉家舟*.(2014) 中藥抑制HBx所引發之MMP-9表現及肝癌細胞轉移之研究. 北台灣中醫醫學雜誌.6(2); P1-14 (非SCI)
  14. Wang SD, Chen BC, Kao ST, Liu CJ, Yeh CC*. Genistein inhibits tumor invasion by
    suppressing multiple signal transduction pathways in human hepatocellular carcinoma cells.
    BMC Complement Altern Med. 2014 Jan 16;14:26. (SCI) (IF=2.08)
  15. Yeh CC, Lin YC, Tsai FJ, Huang CY, Yao CH, Chen YS. Timing of Applying Electrical Stimulation Isan Important Factor Deciding the Success Rate and Maturity of Regenerating Rat Sciatic Nerves.Neurorehabil Neural Repair.2 Neurorehabil Neural Repair. 2010 t;24(8):730-5. (IF=5.3, top:91.%(15/167);JPA:75)
  16. Lee KH, Yeh MH, Kao ST, Hung CM, Liu CJ, Huang YY, Yeh CC*. The inhibitory effect ofhesperidin on tumor cell invasiveness occurs via suppression of activator protein 1 and nuclearfactor-kappaB in human hepatocellular carcinoma cells. ToxicolLett. 2010;194(1-2):42-49. (IF=3.12top 89.4%(8/75); JPA:75)
  17. Hung CM?, Yeh CC?, Chen HL, Lai CW, Kuo MF, Yeh MH, Lin W, Tu MY, Cheng HC, Chen CM.Porcine lactoferrin administration enhances peripheral lymphocyte proliferation and assists infectiousbursal disease vaccination in native chickens. Vaccine. 2010;28(16):2895-902. (?共同第一位者)(IF=3.2 top 99.3%(1/135); JPA:75)
  18. Lee KH, Yeh MH, Kao ST, Hung CM, Chen BC, Liu CJ, Yeh CC*. Xia-bai-san inhibitslipopolysaccharide-induced activation of intercellular adhesion molecule-1 and nuclear factor-kappa Bin human lung cells. J Ethnopharmacol. 2009;124(3):530-8. (SCI) (IF=2.26 top 79%(3/14); JPA:60)
  19. Yeh MH, Kao ST, Hung CM, Liu CJ, Lee KH, Yeh CC*. Hesperidin inhibited acetaldehyde-inducedmatrix metalloproteinase-9 gene expression in human hepatocellular carcinoma cells.ToxicolLett.2009;184(3):204-10. (IF=3.12 top 89.4%(8/75); JPA:75)
  20. Hung CM?, Yeh CC, Chen HL?, Chong KU, Kao ST, Yeh MH, Lin MS, Chen SM*. Gingyo-SanEnhances Immunity and Assists Infectious Bursal Disease Vaccination. Evidence BasedComplementary and Alternative Medicine. 2009 1~10 (IF=2.5 top 64.3%(5/14); JPA:36)
  21. Yeh MH, Hunge CM, Yeh CC*. The molecular medicinal level of Yin Zhi.Taiwan Association ofChinese Medicine of Family journal. 2009;3(1)1-6 (非SCI)
  22. Yeh CM, Haung CW, Yeh CC*, Ting CK, Chen Zen-Yi, Lin NW*. Analysis of breast cancer by meansof Meridian energy. The journal of clinicsl traditional medicine, 2009:15(3)229-235(非SCI) (?共同通訊作者)
  23. Yeh CM、Yeh CC、Hung CM, LAN YM. An inquiry into pathomechanism of idiopathic fever byconductance measurement of acupuncture points. The journal of clinicsl traditional medicine, 2008:14(1)1-12(非SCI)
  24. Hunge CM, Yeh MH, Lee KH, Yeh CC*. The effect of tranditionalchinese medicinal formula onanti-inflammation and immunomodulation in lung cells. Taiwan Association of Chinese Medicine ofFamily journal 2007;2(1):25-35 (非SCI)
  25. Yeh CC, Kao SJ, Lin CC, Wang SD, Liu CJ, Kao ST. 2007; The immunomodulation of endotoxin-induced acute lung injury by hesperidin in vivo and in vitro. Life Sci. 80(20):1821-31. (SCI,)[IF=2.257; Top53.7% (95/205; JPA:45)]
  26. Yeh CC, Lin CC, Wang SD, Hung CM, Yeh MH, Liu CJ, Kao ST. 2007; Protective andimmunomodulatory effect of Gingyo-san in a murine model of acute lung inflammation. JEthnopharmacol. 111(2):418-26 (SCI) [IF=2.049; Top 75% (3/12; JPA:60)]
  27. Yeh CC, Lin CC, Wang SD, Chen YS, Su BH, Kao ST. 2006; Protective andanti-inflammatory effectof a traditional Chinese medicine, Xia-Bai-San, by modulating lung local cytokine in a murine modelof acute lung injury. IntImmunopharmacol. 6(9):1506-14. (SCI) [IF=2.066; Top 49.8% (103/205;JPA:45)]
  28. Yeh MH, Lan YM, Yeh CC*. 2007 Immunomodulatation effect of YnChyau San in BALB/cmice ofacute lung inflammation Taiwan Association of Chinese Medicine of Family journal ;2(1): 13-22. (非sci) [JPA:30]
  29. Zhao DC, Yeh CC, Liu XR, Li CX. 2005 The anti-inflammatory effect of acupuncture. The journal ofclinicsl traditional medicine. 11(4):294-305. (非sci) [JPA:12]
  30. Lee KH , Yeh CC, Chen JY, Kuo SY, Lee SJ, Chang CL, Chi CH. 2007; Decreasing the high somaticcell count in dairy cattle by using Chinese herbal medicine-Pu-Gong-Ying Shan. Journal of TaiwanLivestock Research. 40(4): (非SCI)
  31. Hung CM, Yeh CC, Yeh MH, Lin YF, Chen TF, Lui HL, Shih B, Tsai MY, Chen YS, Hsieh CH, HuangHC, Hsu JC. 2007. Effects of feed added with Chinese herbs on the growth perfornace and featherlesion of native chickens native chickens. Journal of Chinese society animal science 36(suppl):245(非SCI)

(B)研討會論文

  1. Chia-Chou Yeh, Shung-Tekao. 2006; Differential genomic expression of asthma animal model inheat-TCM or cold-TCM.The 7th symposium of the national research program for genomic medicine.
  2. Chia-Chou Yeh, Ming-HsienYeh, Bai-Horng Su, Tin-Yun Ho, Shung-Te Kao 2007; Antipyretic activityof herbal used to Respiratory Distress Syndrome of Preterm Infants. The 14th international congress oforiental medicine.
  3. Ming-HsienYeh, Chia-Chou Yeh, Yin-Ming Lan 2007; An inquiry into Pathomechanism of idiopathicfever by conductance measurement of acupuncture points. The 14th internationalcongress of orientalmedicine.

(C)專書及專書論文

  1. Chia-Chou Yeh2007 Protective and Immunomodulatory effect of Gin-Gyo-San in a murine model of acutelung inflammation. 博士論文

 

 

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